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Tumor microenvironments

Taking the temperature of lung cancer antigens

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Antigen presentation is fundamental to anti-tumor immunity, but our understanding of the physiological and molecular inputs to the process in different contexts remains limited. Two new studies explore the contribution of cell-intrinsic proteolytic mechanisms and cell-extrinsic hot and cold tumor microenvironments in shaping the antigenic landscape in lung cancer.

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Fig. 1: The repertoire of antigens presented on the surface of malignant and non-malignant cells is shaped by ‘hot’ or ‘cold’ immune microenvironments.

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Authors and Affiliations

  1. Department of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA

    Paul A. Stewart

  2. Department of Molecular Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA

    Alex M. Jaeger

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  1. Paul A. Stewart
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  2. Alex M. Jaeger
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Correspondence to Alex M. Jaeger.

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Stewart, P.A., Jaeger, A.M. Taking the temperature of lung cancer antigens. Nat Cancer 4, 586–587 (2023). https://doi.org/10.1038/s43018-023-00552-9

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