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Whole-genome sequencing

Enhancing childhood cancer targetability

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Overall survival for children with rare, relapsed, metastatic and/or refractory cancers has remained unacceptably low over the past four decades. A new precision oncology study introduces an integrative germline and somatic sequencing approach that could breach this impasse to advance cures for children with cancer.

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Fig. 1: Integrative germline and somatic sequencing and data analysis expands the repertoire of clinically actionable targets in pediatric cancer.

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Authors and Affiliations

  1. Center for Data-Driven Discovery in Biomedicine, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Ammar S. Naqvi & Jo Lynne Rokita

  2. Division of Neurosurgery, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Ammar S. Naqvi & Jo Lynne Rokita

  3. Department of Bioinformatics and Health Informatics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA

    Ammar S. Naqvi & Jo Lynne Rokita

Authors
  1. Ammar S. Naqvi
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  2. Jo Lynne Rokita
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Correspondence to Jo Lynne Rokita.

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Naqvi, A.S., Rokita, J.L. Enhancing childhood cancer targetability. Nat Cancer 4, 153–155 (2023). https://doi.org/10.1038/s43018-022-00472-0

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