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An RNA link for METTL16 and DNA repair in PDAC

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Increasing evidence links RNA methyltransferases to DNA damage repair. METTL16 is now shown to antagonize homologous recombination by preventing DNA-end resection via MRE11. Thus, METTL16 may represent a cancer vulnerability that can be used to identify patients able to benefit from combination therapies with DNA-damaging agents.

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Fig. 1: PDAC tumors with high METTL16 are deficient in DNA repair and more sensitive to combination therapy.

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Authors and Affiliations

  1. Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA

    Marcelo Perez-Pepe & Claudio R. Alarcón

  2. Yale Cancer Biology Institute, Yale University, West Haven, CT, USA

    Marcelo Perez-Pepe & Claudio R. Alarcón

Authors
  1. Marcelo Perez-Pepe
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  2. Claudio R. Alarcón
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Correspondence to Claudio R. Alarcón.

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The authors declare no competing interests.

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Perez-Pepe, M., Alarcón, C.R. An RNA link for METTL16 and DNA repair in PDAC. Nat Cancer 3, 1018–1020 (2022). https://doi.org/10.1038/s43018-022-00434-6

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