Mitochondrial fission in macrophages is essential for the phagocytosis of tumor cells. Resistance of tumor cells to phagocytosis involves overexpression of GFPT2, an enzyme involved in glutamine metabolism; this results in lower nutrient availability for macrophages to support mitochondrial fission and prevents assembly of the phagocytic machinery.
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This is a summary of: Li, J. et al. Macrophage mitochondrial fission improves cancer cell phagocytosis induced by therapeutic antibodies and is impaired by glutamine competition. Nat. Cancer https://doi.org/10.1038/s43018-022-00354-5 (2022).
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Mitochondrial fission in macrophages fuels phagocytosis of tumor cells. Nat Cancer 3, 384–385 (2022). https://doi.org/10.1038/s43018-022-00350-9
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DOI: https://doi.org/10.1038/s43018-022-00350-9
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