A potential translational strategy to treat brain metastases is the induction or maintenance of proliferative dormancy in tumor cells. A new study shows that dormancy in breast cancer brain metastasis is maintained in the perivascular niche by astrocyte endfoot secretion of laminin-211, causing tumor cell membrane sequestration of YAP.
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Khan, I., Steeg, P.S. Keeping brain metastases dormant. Nat Cancer 3, 3–5 (2022). https://doi.org/10.1038/s43018-021-00321-6
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DOI: https://doi.org/10.1038/s43018-021-00321-6
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