Pseudouridine is the most abundant RNA modification, but its biological role remains poorly understood. A study now finds dysregulated pseudouridine synthase PUS7 in glioblastoma and demonstrates that pharmacological inhibition of PUS7 leads to reduced tumorigenesis, which underpins the therapeutic potential of targeting epitranscriptomic regulators in cancer.
References
Cohn, W. E. & Volkin, E. Nature 167, 483–484 (1951).
Spenkuch, F., Motorin, Y. & Helm, M. RNA Biol. 11, 1540–1554 (2014).
Nombela, P., Miguel-Lopez, B. & Blanco, S. Mol. Cancer 20, 18 (2021).
Cui, Q. et al. Nat. Cancer https://doi.org/10.1038/s43018-021-0238-0 (2021).
Lathia, J. D. et al. Genes Dev. 29, 1203–1217 (2015).
Marine, J. C., Dawson, S. J. & Dawson, M. A. Nat. Rev. Cancer 20, 743–756 (2020).
Heiss, N. S. et al. Nat. Genet. 19, 32–38 (1998).
Guzzi, N. et al. Cell 173, 1204–1216.e1226 (2018).
Krstulja, A. et al. Macromol. Biosci. 17, 1700250 (2017).
Zeleznik, O. A. et al. Cancer Res. 80, 1357–1367 (2020).
Sridharan, G., Ramani, P., Patankar, S. & Vijayaraghavan, R. J. Oral Pathol. Med. 48, 299–306 (2019).
Su, R. et al. Cell 172, 90–105.e123 (2018).
Yankova, E. et al. Nature 593, 597–601 (2021).
Cui, Q. et al. Cell Rep. 18, 2622–2634 (2017).
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Morón-Calvente, V., Blanco, S. A therapy PUSh for GBM. Nat Cancer 2, 876–878 (2021). https://doi.org/10.1038/s43018-021-00255-z
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DOI: https://doi.org/10.1038/s43018-021-00255-z
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