Replication stress fuels chromosomal instability, tumor heterogeneity and therapy resistance. The Sonic hedgehog pathway is now linked to an unorthodox form of replication stress in cerebellar granular-cell progenitors through deregulated firing of DNA replication origins, with implications for the pathogenesis, genomic instability and treatment of medulloblastoma.
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Maya-Mendoza, A., Bartek, J. Super-sonic speed of DNA synthesis in medulloblastoma. Nat Cancer 1, 758–760 (2020). https://doi.org/10.1038/s43018-020-0105-8
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DOI: https://doi.org/10.1038/s43018-020-0105-8
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