Tumor heterogeneity remains an obstacle to effective clinical management of breast cancer. Two new studies use high-dimensional imaging of single-cell protein expression in situ in clinical samples to link genomic alterations to multi-cellular features of the tumor microenvironment and reveal breast-cancer phenotypes associated with clinical outcome.
This is a preview of subscription content, log in via an institution to check access.
References
Jackson, H. W. et al. Nature https://doi.org/10.1038/s41586-019-1876-x (2020).
Ali, H. R. et al. Nat. Cancer https://doi.org/10.1038/s43018-020-0026-6 (2020).
Binnewies, M. et al. Nat. Med. 24, 541–550 (2018).
Keren, L. et al. Cell 174, 1373–1387.e19 (2018).
Hausser, J. et al. bioRxiv https://doi.org/10.1101/382291 (2018).
Dvinge, H. et al. Nature 497, 378–382 (2013).
Curtis, C. et al. Nature 486, 346–352 (2012).
Pereira, B. et al. Nat. Commun. 7, 11479 (2016).
Schapiro, D. et al. Nat. Methods 14, 873–876 (2017).
Goltsev, Y. et al. Cell 174, 968–981.e15 (2018).
Grün, D. et al. Cell Stem Cell 19, 266–277 (2016).
Schürch, C. M. et al. bioRxiv https://doi.org/10.1101/743989 (2019).
Arnol, D., Schapiro, D., Bodenmiller, B., Saez-Rodriguez, J. & Stegle, O. Cell Rep. 29, 202–211.e6 (2019).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no competing interests.
Rights and permissions
About this article
Cite this article
Keren, L., Angelo, M. Mapping cell phenotypes in breast cancer. Nat Cancer 1, 156–157 (2020). https://doi.org/10.1038/s43018-020-0031-9
Published:
Issue Date:
DOI: https://doi.org/10.1038/s43018-020-0031-9
- Springer Nature America, Inc.