Skip to main content
SpringerLink
Log in

DEEP LEARNING IN MEDICINE

Predicting cracks in metalloproteins

  • News & Views
  • Published:

From Nature Machine Intelligence

View current issue Submit your manuscript

Loss-of-function mutations in metal-binding proteins are heavily implicated with numerous diseases, and identifying such ‘cracks’ will be valuable to biologists and medical doctors in the study and treatment of disease. A deep learning approach has been developed to tackle this challenging task.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: A deep-learning approach to predict whether mutations around metal-binding sites in metalloproteins are disease-relevant or benign.

References

  1. Waldron, K. J. & Robinson, N. J. Nat. Rev. Microbiol. 7, 25 (2009).

    Article  Google Scholar 

  2. Forget, B. G. & Bunn, H. F. Cold Spring Harb. Perspect. Med. 3, a011684 (2013).

    Article  Google Scholar 

  3. Koohi-Moghadam, M. et al. Nat. Mach. Intell. https://doi.org/10.1038/s42256-019-0119-z (2019).

  4. Andreini, C., Cavallaro, G., Lorenzini, S. & Rosato, A. Nucleic Acids Res. 41, D312–D319 (2013).

    Article  Google Scholar 

  5. Bamshad, M. J. et al. Nat. Rev. Genet. 12, 745–755 (2011).

    Article  Google Scholar 

  6. Adzhubei, I. A. et al. Nat. Methods 7, 248–249 (2010).

    Article  Google Scholar 

  7. Kuhlman, B. & Bradley, P. Nat. Rev. Mol. Cell Biol. 20, 681–697 (2019).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. College of Chemistry and Molecular Engineering, Peking University, Beijing, China

    Yuan Liu & Chu Wang

Authors
  1. Yuan Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Chu Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Chu Wang.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Liu, Y., Wang, C. Predicting cracks in metalloproteins. Nat Mach Intell 1, 553–554 (2019). https://doi.org/10.1038/s42256-019-0128-y

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s42256-019-0128-y

  • Springer Nature Limited

Search

Navigation