In this issue of Nature Metabolism, the research team of Mitchell Lazar reveals unexpected consequences of double loss of the coregulators NCOR1 and NCOR2 (NCOR1/2) in hepatocytes of adult mice, which affects chromatin functioning and glucocorticoid receptor (GR)-mediated gene transcription.
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References
Scholtes, C. & Giguère, V. Nat. Rev. Mol. Cell Biol. 23, 750–770 (2022).
Shabtai, Y. et al. Genes Dev 35, 367–378 (2021).
Stashi, E., York, B. & O’Malley, B. W. Trends Endocrinol. Metab. 25, 337–347 (2014).
Liang, N., Jakobsson, T., Fan, R. & Treuter, E. Front. Endocrinol. 10, 411 (2019).
Hauck, A. K. et al. Nat. Metab. https://doi.org/10.1038/s42255-024-01029-4 (2024).
Rogatsky, I., Luecke, H. F., Leitman, D. C. & Yamamoto, K. R. Proc. Natl Acad. Sci. USA 99, 16701–16706 (2002).
Rollins, D. A. et al. Nat. Commun. 8, 1739 (2017).
Dendoncker, K. et al. Proc. Natl Acad. Sci. USA 116, 12942–12951 (2019).
Van Moortel, L. et al. Mol. Cell. Proteomics https://doi.org/10.1016/j.mcpro.2024.100741 (2024).
Fadel, L. et al. Pharmacol. Ther. 251, 108531 (2023).
Vella, K. R. et al. Mol. Cell. Biol. 34, 1564–1575 (2014).
Hemmer, M. C. et al. Nat. Commun. 10, 306 (2019).
Lee, R. A. et al. Nat. Commun. 14, 3143 (2023).
Harrison, S. A. et al. N. Engl. J. Med 390, 497–509 (2024).
Lefere, S. et al. J. Hepatol. 73, 757–770 (2020).
Acknowledgements
The authors receive research support from VIB (KadBo), the Research Foundation Flanders (FWO) (G0A5124N) and UGent BOF/24J/2021/374.
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Van Leene, C., De Bosscher, K. NCOR1/2 and glucocorticoid receptor orchestrate hepatic function. Nat Metab (2024). https://doi.org/10.1038/s42255-024-01028-5
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DOI: https://doi.org/10.1038/s42255-024-01028-5
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