Optimization of energy and carbon–nitrogen allocation maximizes the proliferation and functionality of chimeric antigen receptor (CAR)-T cells. Lakhani et al. report that tonic signalling elements (scFvs) affect CAR-T cell metabolic fitness in an antigen-independent manner. A modest carbon–nitrogen emission (overflow) and resilient metabolic phenotype (compatibility) are associated with effective CAR-T cell therapy.
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Wang, H., Huang, Y. & Wang, R. Tonic-ing emissions and compatibility to turbocharge CAR-T. Nat Metab (2024). https://doi.org/10.1038/s42255-024-01022-x
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DOI: https://doi.org/10.1038/s42255-024-01022-x
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