The microbiome is implicated in a study that involves the metabolism of dietary fibre into short-chain fatty acids, which provides a biochemical link to the poorly understood histone butyrylation.
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References
Gates, L. A. et al. Nat. Metab. https://doi.org/10.1038/s42255-024-00992-2 (2024).
Jaenisch, R. & Bird, A. Nat. Genet. 33, 245–254 (2003). Suppl.
Musselman, C. A., Lalonde, M. E., Côté, J. & Kutateladze, T. G. Nat. Struct. Mol. Biol. 19, 1218–1227 (2012).
Dai, Z., Ramesh, V. & Locasale, J. W. Nat. Rev. Genet. 21, 737–753 (2020).
Reid, M. A., Dai, Z. & Locasale, J. W. Nat. Cell Biol. 19, 1298–1306 (2017).
Miro-Blanch, J. & Yanes, O. Front. Genet. 10, 638 (2019).
Chen, Y. et al. Mol. Cell. Proteomics 6, 812–819 (2007).
Sabari, B. R., Zhang, D., Allis, C. D. & Zhao, Y. Nat. Rev. Mol. Cell Biol. 18, 90–101 (2017).
Koh, A., De Vadder, F., Kovatcheva-Datchary, P. & Bäckhed, F. Cell 165, 1332–1345 (2016).
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This work was supported by R01 CA193256
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Sun, Y., Locasale, J.W. Histone butyrylation is a dietary link to epigenetics. Nat Metab 6, 606–607 (2024). https://doi.org/10.1038/s42255-024-01013-y
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DOI: https://doi.org/10.1038/s42255-024-01013-y
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