Eating requires the sensing in the stomach of not only nutrients, but also volume. A study in Nature Metabolism shows that stretch activation of PIEZO1 on X/A-like cells of the stomach reduces ghrelin production and secretion, which consequently reduces food intake.
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Lam, C.S.D., Kaelberer, M.M. The pressure not to eat. Nat Metab 6, 380–381 (2024). https://doi.org/10.1038/s42255-024-01002-1
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DOI: https://doi.org/10.1038/s42255-024-01002-1
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