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Resisting weight gain with prebiotic fibre

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Resistant starch is a prebiotic fibre that is fermented by the gut microbiota and leads to benefits for host physiology. A clinical trial in Nature Metabolism demonstrates weight loss when resistant starch was given to individuals with excess weight.

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Fig. 1: Promoting weight loss with a type 2 resistant-starch prebiotic fibre.

References

  1. Fan, Y. & Pedersen, O. Nat. Rev. Microbiol. 19, 55–71 (2021).

    Article  CAS  PubMed  Google Scholar 

  2. Gibson, G. R. et al. Nat. Rev. Gastroenterol. Hepatol. 14, 491–502 (2017).

    Article  PubMed  Google Scholar 

  3. Van Hul, M. & Cani, P. D. Nat. Rev. Endocrinol. 19, 258–271 (2023).

    Article  PubMed  Google Scholar 

  4. Deehan, E. C. et al. Cell Host Microbe 27, 389–404.e6 (2020).

    Article  CAS  PubMed  Google Scholar 

  5. Venkataraman, A. et al. Microbiome 4, 33 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Dobranowski, P. A. & Stintzi, A. Gut Microbes 13, 1926842 (2021).

    Article  PubMed  PubMed Central  Google Scholar 

  7. Baxter, N. T. et al. MBio 10, e02566–18 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Li, H. et al. Nat. Metab. https://doi.org/10.1038/s42255-024-00988-y (2024).

    Article  PubMed  Google Scholar 

  9. de Boer, J. F., Bloks, V. W., Verkade, E., Heiner-Fokkema, M. R. & Kuipers, F. Curr. Opin. Lipidol. 29, 194–202 (2018).

    Article  PubMed  Google Scholar 

  10. Zwartjes, M. S. Z., Gerdes, V. E. A. & Nieuwdorp, M. Metabolites 11, 531 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Korecka, A. et al. Am. J. Physiol. Gastrointest. Liver Physiol. 304, G1025–G1037 (2013).

    Article  CAS  PubMed  Google Scholar 

  12. Upadhyaya, B. et al. Sci. Rep. 6, 28797 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Sonnenburg, E. D. & Sonnenburg, J. L. Nat. Rev. Microbiol. 17, 383–390 (2019).

    Article  CAS  PubMed  Google Scholar 

  14. Wastyk, H. C. et al. Cell 184, 4137–4153.e14 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Sonnenburg, E. D. & Sonnenburg, J. L. Cell Metab. 20, 779–786 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

S.P.S was funded by National Institutes of Health grant 5T32DK007056 and 1K08DK134856.

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Correspondence to Sean P. Spencer.

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Carter, M.M., Spencer, S.P. Resisting weight gain with prebiotic fibre. Nat Metab 6, 389–391 (2024). https://doi.org/10.1038/s42255-024-00998-w

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