Individuals with osteoporosis have increased risk of Alzheimer’s disease or cognitive impairment during ageing. We elucidated a partial explanation for bone dysmetabolism’s association with such cognitive decline, by demonstrating how elevated sclerostin secretion from osteocytes in bone impaired cognitive function in aged mice and in an Alzheimer’s disease mouse model.
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References
Chang, K. H. Increased risk of dementia in patients with osteoporosis: a population-based retrospective cohort analysis. Age (Dordr) 36, 967–975 (2014). This paper reports that osteoporosis patients exhibited 1.46-fold and 1.39-fold high risk of dementia and Alzheimer’s disease, respectively.
Han, Y., You, X., Xing, W., Zhang, Z. & Zou, W. Paracrine and endocrine actions of bone-the functions of secretory proteins from osteoblasts, osteocytes, and osteoclasts. Bone Res. 6, 16 (2018). A review that presents how bone cells, includingosteoclasts, osteoblasts and osteocytes, can act as endocrine organs to regulate the homeostasis of other organs.
Schaffler, M. B. Osteocyte signaling in bone. Curr. Osteoporos. Rep. 10, 118–125 (2012). This paper reports that osteocytes residing within the bone matrix make up between 90% to 95% of cellular components in mature bone tissue.
Dallas, S. L., Prideaux, M. & Bonewald, L. F. The osteocyte: an endocrine cell … and more. Endocrinol. Rev. 34, 658–690 (2013). A review that presents how osteocytes secret sclerostin to inhibit osteoblastogenesis by dysregulating the Wnt–β-catenin pathway.
Yuan, J. et al. Elevated plasma sclerostin is associated with high brain amyloid-beta load in cognitively normal older adults. npj Aging 9, 17 (2023). This paper reports that high plasma sclerostin is positively associated with high brain Aβ loading in older adults.
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This is a summary of: Shi, T. et al. Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer’s disease progression. Nat. Metab. https://doi.org/10.1038/s42255-024-00989-x (2024).
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Sclerostin secreted from bone mediates cognitive decline in the brains of aged and Alzheimer’s disease mice. Nat Metab 6, 394–395 (2024). https://doi.org/10.1038/s42255-024-00990-4
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DOI: https://doi.org/10.1038/s42255-024-00990-4
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