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Accumulation of G3P and pEtN drives cellular senescence via altered lipid metabolism

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Glycerol-3-Phosphate (G3P) and phosphoethanolamine (pEtN) biosynthetic pathways are modulated during senescence establishment to sustain lipid droplet accumulation and senescence-associated secretome. These findings reveal new targets for an immunomodulatory approach against senescent cells.

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Fig. 1: G3P and pEtN are part of a senescence-associated metabolic signature.

References

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This is a summary of: Tighanimine, K. et al. A homoeostatic switch causing glycerol-3-phosphate and phosphoethanolamine accumulation triggers senescence by rewiring lipid metabolism. Nat. Metab. https://doi.org/10.1038/s42255-023-00972-y (2024).

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Accumulation of G3P and pEtN drives cellular senescence via altered lipid metabolism. Nat Metab 6, 205–206 (2024). https://doi.org/10.1038/s42255-024-00975-3

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