Calcium sensing receptor (CaSR) and peptide transporter 1 (PepT1) have been implicated in protein sensing in the gut, although the mechanisms are poorly understood. We find that, in the small intestine, CasR and PepT1 are necessary for protein sensing to regulate gut peptide release, feeding and glucose tolerance in rats in vivo.
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References
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This is a summary of: Li, R. J. W. et al. Small intestinal CaSR-dependent and CaSR-independent protein sensing regulates feeding and glucose tolerance in rats. Nat. Metab. https://doi.org/10.1038/s42255-023-00942-4 (2024).
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Small intestinal protein sensing pathways regulate food intake and glucose homeostasis. Nat Metab 6, 14–15 (2024). https://doi.org/10.1038/s42255-023-00947-z
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DOI: https://doi.org/10.1038/s42255-023-00947-z
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