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Reprogramming

Vitamin B12 emerges as key player during cellular reprogramming

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By analysing the effect of disrupting microbiota during in vivo reprogramming, Kovatcheva et al. demonstrated that vitamin B12-dependent metabolism is a limiting factor for cellular reprogramming and plasticity, and propose its therapeutic supplementation for the improvement of tissue repair.

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Fig. 1: Vitamin B12 emerges as key player of cellular reprogramming.

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Acknowledgements

We thank Sara Picó, University of Lausanne, for her comments. The authors’ research is supported by the Milky Way Research Foundation (MWRF), the Eccellenza grants from the Swiss National Science Foundation (SNSF), the University of Lausanne, and the Canton Vaud. Gabriela Desdín-Micó was supported by the EMBO postdoctoral fellowship (EMBO ALTF 444-2021).

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Authors and Affiliations

  1. Department of Biomedical Sciences, Faculty of Biology and Medicine, University of Lausanne, Lausanne, Vaud, Switzerland

    Alba Vílchez-Acosta, Gabriela Desdín-Micó & Alejandro Ocampo

  2. EPITERNA SA, Epalinges, Vaud, Switzerland

    Alejandro Ocampo

Authors
  1. Alba Vílchez-Acosta
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  2. Gabriela Desdín-Micó
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  3. Alejandro Ocampo
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Corresponding author

Correspondence to Alejandro Ocampo.

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Competing interests

A.O. is co-founder and shareholder of EPITERNA SA and co-founder of Longevity Consultancy Group. All other authors declare no competing interests.

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Vílchez-Acosta, A., Desdín-Micó, G. & Ocampo, A. Vitamin B12 emerges as key player during cellular reprogramming. Nat Metab 5, 1844–1845 (2023). https://doi.org/10.1038/s42255-023-00917-5

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