Skip to main content
SpringerLink
Log in

Gastroenterology

Proline fuels ILC3s to maintain gut health

  • News & Views
  • Published:

From Nature Metabolism

View current issue Submit your manuscript

Group 3 innate lymphoid cells (ILC3s) maintain intestinal barrier integrity and nutrient absorption via IL-22; however, little is known about how these immune cells fuel effector function. Wu et al. now report that uptake of dietary proline acts as a critical metabolic modulator of the ILC3 transcriptome and cytokine production to maintain gut health.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: Dietary proline regulates ILC3 responses to prevent intestinal inflammation.

References

  1. Li, J. H., Hepworth, M. R. & O’Sullivan, T. E. Immunity 56, 1168–1186 (2023).

    Article  CAS  PubMed  Google Scholar 

  2. Vivier, E. et al. Cell 174, 1054–1066 (2018).

    Article  CAS  PubMed  Google Scholar 

  3. Zhou, L., Lin, Q. & Sonnenberg, G. F. Nat. Metab. 4, 1650–1659 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Di Luccia, B., Gilfillan, S., Cella, M., Colonna, M. & Huang, S. C. J. Exp. Med. 216, 2231–2241 (2019).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. King, J. I. et al. Mucosal Immunol. https://doi.org/10.1016/j.mucimm.2023.07.001 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  6. Melo-Gonzalez, F. & Hepworth, M. R. Immunology 150, 265–275 (2017).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Bando, J. K., Liang, H. E. & Locksley, R. M. Nat. Immunol. 16, 153–160 (2015).

    Article  CAS  PubMed  Google Scholar 

  8. Hodge, S. H. et al. J. Exp. Med. 220, e20221073 (2023).

    Article  CAS  PubMed  Google Scholar 

  9. Monticelli, L. A. et al. Nat. Immunol. 17, 656–665 (2016).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Surace, L. et al. Nat. Immunol. 22, 1367–1374 (2021).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Wu, D. Nat. Metab. https://doi.org/10.1038/s42255-023-00908-6 (2023).

    Article  PubMed  PubMed Central  Google Scholar 

  12. Branzk, N., Gronke, K. & Diefenbach, A. Immunol. Rev. 286, 86–101 (2018).

    Article  CAS  PubMed  Google Scholar 

  13. Peng, V. et al. Proc. Natl Acad. Sci. USA 119, e2214900119 (2022).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Diefenbach, A., Gnafakis, S. & Shomrat, O. Immunity 52, 452–463 (2020).

    Article  CAS  PubMed  Google Scholar 

  15. Friedrich, M., Pohin, M. & Powrie, F. Immunity 50, 992–1006 (2019).

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

M.R.H. is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (grant number 105644/Z/14/Z), a BBSRC responsive mode grant (BB/T014482/1) and a Lister Institute of Preventative Medicine Prize.

Author information

Authors and Affiliations

  1. Lydia Becker Institute of Immunology and Inflammation, University of Manchester, Manchester, UK

    Matthew R. Hepworth

  2. Division of Immunology, Immunity to Infection and Respiratory Medicine, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK

    Matthew R. Hepworth

Authors
  1. Matthew R. Hepworth
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Matthew R. Hepworth.

Ethics declarations

Competing interests

The author declares no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Hepworth, M.R. Proline fuels ILC3s to maintain gut health. Nat Metab 5, 1848–1849 (2023). https://doi.org/10.1038/s42255-023-00895-8

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s42255-023-00895-8

  • Springer Nature Limited

This article is cited by

Search

Navigation