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An integrated single-cell islet atlas in health and disease

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A mouse pancreatic islet atlas comprising over 300,000 single-cell transcriptomes was integrated from nine biologically diverse datasets to unify existing knowledge in the islet biology community. This interactively accessible resource reveals new insights into the molecular identity and plasticity of islet and β-cells across sex, life span and diabetes progression.

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Fig. 1: The MIA of single-cell transcriptomes across biological conditions offers new insights into islet and β-cell biology.

References

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This is a summary of: Hrovatin, K. et al. Delineating mouse β-cell identity during lifetime and in diabetes with a single cell atlas. Nat. Metab. https://doi.org/10.1038/s42255-023-00876-x (2023).

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An integrated single-cell islet atlas in health and disease. Nat Metab 5, 1459–1460 (2023). https://doi.org/10.1038/s42255-023-00884-x

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