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Metabolic tuning during the menstrual cycle

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As most studies on the action of insulin in the brain have focused on men, metabolic changes during the menstrual cycle in women remain poorly understood. Using intranasal insulin administration during hyperinsulinaemic–euglycaemic clamps and functional MRI, Hummel et al. show reduced insulin sensitivity during the luteal phase.

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Fig. 1: Intranasal administration of insulin uncovers a heightened insulin sensitivity in women during the follicular phase of the menstrual cycle.

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Acknowledgements

I thank A. Kühnel for valuable feedback on a draft of this work. I received support from the Deutsche Forschungsgemeinschaft, DFG KR 4555/7-1, KR 4555/9-1, KR 4555/10-1 and IRTG 2804.

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Authors and Affiliations

  1. Section of Medical Psychology, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University of Bonn, Bonn, Germany

    Nils B. Kroemer

  2. Department of Psychiatry and Psychotherapy, Tübingen Center for Mental Health, University of Tübingen, Tübingen, Germany

    Nils B. Kroemer

  3. German Center for Mental Health, Tübingen, Germany

    Nils B. Kroemer

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Correspondence to Nils B. Kroemer.

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Kroemer, N.B. Metabolic tuning during the menstrual cycle. Nat Metab 5, 1449–1451 (2023). https://doi.org/10.1038/s42255-023-00867-y

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