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Mechanisms of disease

Anaplerosis in action

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Investigation of multi-omic changes and their effects on regulation of metabolic pathways confirm anaplerotic deficiencies in methylmalonic acidaemia, strengthening the need for future therapies aimed at replenishing intermediates of the tricarboxylic acid cycle.

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Fig. 1: Dysregulation of anaplerosis and the TCA cycle in MMA.

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Authors and Affiliations

  1. National Institute of General Medical Sciences, National Institutes of Health, Bethesda, MD, USA

    PamelaSara E. Head

  2. National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, USA

    PamelaSara E. Head & Charles P. Venditti

Authors
  1. PamelaSara E. Head
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  2. Charles P. Venditti
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Correspondence to Charles P. Venditti.

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The authors declare no competing interests.

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Head, P.E., Venditti, C.P. Anaplerosis in action. Nat Metab 5, 5–7 (2023). https://doi.org/10.1038/s42255-022-00724-4

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