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Abdominal transplantation of pancreatic islets to protect against type 1 diabetes

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Human pluripotent stem cell-derived pancreatic islets (PSC-islets) hold promise in type I diabetes treatment, although their delivery is a challenge. We describe a new abdominal infusion transplantation protocol that enables the survival, maturation and maintenance of functional PSC-islets in diabetic monkeys.

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Fig. 1: Improved hormone production by CiPSC-islet grafts following sub-rectus sheath transplantation.

References

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Publisher’s note Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

This is a summary of: Liang, Z. et al. Implantation underneath the abdominal anterior rectus sheath enables effective and functional engraftment of stem-cell-derived islets. Nat. Metab. https://doi.org/10.1038/s42255-022-00713-7 (2023).

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Abdominal transplantation of pancreatic islets to protect against type 1 diabetes. Nat Metab 5, 19–20 (2023). https://doi.org/10.1038/s42255-022-00714-6

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  • DOI: https://doi.org/10.1038/s42255-022-00714-6

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