PRDM16 is a key mediator of thermogenic fat, counteracting adipose fibrosis and inflammation. Kajimura and co-authors demonstrate that a CUL2–APPBP2 ubiquitin E3 ligase complex destabilizes the PRDM16 protein, resulting in declined metabolic activity in an age-dependent manner.
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Horvath, C., Scheele, C. PRDM16 stability and metabolically healthy adipose tissue. Nat Metab 4, 1095–1096 (2022). https://doi.org/10.1038/s42255-022-00639-0
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DOI: https://doi.org/10.1038/s42255-022-00639-0
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