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ENDOTHELIAL METABOLISM

YAP/TAZ–TEAD link angiogenesis to nutrients

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Ong et al. uncover a role for the YAP/TAZ–TEAD transcriptional pathways in retinal angiogenesis via the regulation of amino acid transporters and assessed mTORC activation. These findings establish the mechanism through which endothelial cells regulate nutrient acquisition and consumption.

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Fig. 1: YAP/TAZ–TEAD pathway supports retinal angiogenesis by controlling nutrient transporter levels and mTORC1 activation.

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Authors and Affiliations

  1. Laboratory of Angiogenesis and Redox Metabolism, Department of Biology, University of Padua, Padua, Italy

    Roxana E. Oberkersch & Massimo M. Santoro

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  1. Roxana E. Oberkersch
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  2. Massimo M. Santoro
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Correspondence to Massimo M. Santoro.

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The authors declare no competing interests.

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Oberkersch, R.E., Santoro, M.M. YAP/TAZ–TEAD link angiogenesis to nutrients. Nat Metab 4, 645–646 (2022). https://doi.org/10.1038/s42255-022-00579-9

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