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Reducing NAD(H) to amplify rhythms

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Levine and colleagues demonstrate that the effects of caloric restriction on hepatic gene expression, circulating acylcarnitines and body temperature are largely mediated by an increase in the daytime peak of NADH concentration in the liver.

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Fig. 1: Caloric restriction suppresses daytime hepatic clock output by increasing NADH.

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Acknowledgements

The authors received research support from the US National Institutes of Health (DK098656 to J.A.B.) and a Career Development Award from the Crohn’s & Colitis Foundation to K.C. (581355).

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Authors and Affiliations

  1. Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Karthikeyani Chellappa & Joseph A. Baur

  2. Institute for Diabetes, Obesity, and Metabolism, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Karthikeyani Chellappa & Joseph A. Baur

Authors
  1. Karthikeyani Chellappa
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  2. Joseph A. Baur
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Correspondence to Joseph A. Baur.

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Competing interests

J.A.B. is a consultant to Pfizer and Cytokinetics, an inventor on a patent for using NAD+ precursors in liver injury, and has received research funding and materials from Elysium Health and Metro International Biotech, both of which have an interest in NAD+ precursors. K.C. declares no competing interests.

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Chellappa, K., Baur, J.A. Reducing NAD(H) to amplify rhythms. Nat Metab 3, 1589–1590 (2021). https://doi.org/10.1038/s42255-021-00494-5

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