Clearance of dMiro from the outer mitochondrial membrane is a prerequisite for mitophagy of dysfunctional mitochondria. Li et al. find that oxidative stress stabilizes dMiro via its interaction with dMIC60. Dissociating this complex by genetic or pharmacologic interventions counteracts neurological aging in flies.
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Acknowledgements
Writing of this article was founded by the “Regenerative Mechanisms for Health” project MAB/2017/2 carried out within the International Research Agendas programme of the Foundation for Polish Science co-financed by the European Union under the European Regional Development Fund and was supported by an OPUS grant of National Science Centre, Poland, 2019/35/B/NZ3/04095.
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Wasilewski, M., Chacinska, A. MIC60 relays oxidation to block mitophagy. Nat Metab 3, 1146–1147 (2021). https://doi.org/10.1038/s42255-021-00460-1
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DOI: https://doi.org/10.1038/s42255-021-00460-1
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