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DEVELOPMENTAL BIOLOGY

Oocyte metabolites are heritable factors that drive metabolic reprogramming of the progeny

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The maternal diet can impact offspring development, yet the mechanisms responsible for this remain largely unknown. New research shows that oocyte metabolites, specifically NAD+ and the methyl donor S-adenosylmethionine, can mediate the impact of maternal nutrient stress on the progeny through metabolic reprogramming in Drosophila.

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Fig. 1: Oocyte metabolites serve as the potential heritable factors that drive reprogramming of progeny metabolism.

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Authors and Affiliations

  1. State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China

    Shuai Zhu & Qiang Wang

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  1. Shuai Zhu
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  2. Qiang Wang
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Correspondence to Qiang Wang.

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The authors declare no competing interests.

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Zhu, S., Wang, Q. Oocyte metabolites are heritable factors that drive metabolic reprogramming of the progeny. Nat Metab 3, 1148–1149 (2021). https://doi.org/10.1038/s42255-021-00447-y

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