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Run to survive—how preoperative exercise could prevent major surgical complications

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Preoperative exercise and a high fitness level can confer protection against postoperative stress. In this issue, Zhang et al. report that a short 4-week exercise regimen before liver surgery induces beneficial immunometabolic adaptations in Kupffer cells. Notably, the exercise-induced expression of immune-responsive gene 1 (Irg1) drives Kupffer cells toward an anti-inflammatory phenotype with decreased markers of postoperative hepatic ischaemia–reperfusion injury.

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Fig. 1: Preoperative exercise protects against hepatic inflammation by inducing beneficial immunometabolic alterations in Kupffer cells.

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Authors and Affiliations

  1. Technische Universiät Braunschweig, Department of Bioinfomatics and Biochemistry, Braunschweig Integrated Center of Systems Biology (BRICS), Braunschweig, Germany

    Alexander Heinz & Karsten Hiller

  2. Computational Biology of Infection Research, Helmholtz Centre for Infection Research, Braunschweig, Germany

    Karsten Hiller

Authors
  1. Alexander Heinz
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  2. Karsten Hiller
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Correspondence to Karsten Hiller.

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The authors declare no competing interests.

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Heinz, A., Hiller, K. Run to survive—how preoperative exercise could prevent major surgical complications. Nat Metab 3, 732–734 (2021). https://doi.org/10.1038/s42255-021-00403-w

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