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CELL MOTILITY

Endothelial metabolism going single

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Endothelial cell migration is indispensable for (tumour) angiogenesis and is fuelled by glycolysis. The metabolic underpinnings have been only partially unravelled to date, partly because of the lack of appropriate tools to analyse metabolic flux at the single-cell level. In this issue, Wu et al. introduce a novel imaging assay to capture glycolytic flux during motion in single endothelial cells. With this new tool, the authors uncovered a glycolysis-driven cytoskeletal remodelling apparatus that propels endothelial cell motility.

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Fig. 1: Glycolysis-driven cytoskeletal remodelling during endothelial cell migration.

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Acknowledgements

P.C. is supported by grants from Methusalem funding (Flemish government), the Fund for Scientific Research-Flanders (FWO-Vlaanderen) and the European Research Council (ERC Advanced Research Grant EU- ERC743074); L.M.B. is supported by a Marie-Curie fellowship. The authors thank M. Dewerchin for help with the manuscript.

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Authors and Affiliations

  1. Laboratory of Angiogenesis & Vascular Metabolism, Center for Cancer Biology, VIB, Leuven, Belgium

    Abhishek Subramanian, Lisa M. Becker & Peter Carmeliet

  2. Laboratory of Angiogenesis & Vascular Metabolism, Department of Oncology, KU Leuven, Leuven, Belgium

    Abhishek Subramanian, Lisa M. Becker & Peter Carmeliet

  3. Laboratory of Angiogenesis & Vascular Heterogeneity, Department of Biomedicine, Aarhus University, Aarhus, Denmark

    Peter Carmeliet

  4. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, Guangdong, P.R. China

    Peter Carmeliet

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  1. Abhishek Subramanian
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  2. Lisa M. Becker
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  3. Peter Carmeliet
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Correspondence to Peter Carmeliet.

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P.C. is named as an inventor on patent applications claiming subject matter related to results described in this article. The other authors declare no competing interests.

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Subramanian, A., Becker, L.M. & Carmeliet, P. Endothelial metabolism going single. Nat Metab 3, 593–594 (2021). https://doi.org/10.1038/s42255-021-00399-3

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