Nutrient availability dictates cell differentiation and transition through the Dictyostelium discoideum life cycle. Kelly et al. reveal that the increase in reactive oxygen species associated with nutrient limitation coincides with a sequestration of available cysteine in glutathione, thus limiting sulfur-dependent mitochondrial respiration and promoting aggregation into the differentiated spore form.
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Ward, N.P., DeNicola, G.M. GSH hoards all the cysteine—what a slimy thing to do. Nat Metab 3, 297–298 (2021). https://doi.org/10.1038/s42255-021-00365-z
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DOI: https://doi.org/10.1038/s42255-021-00365-z
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