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INSULIN SIGNALLING

A co-receptor that represses beta-cell insulin action

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Exhaustion of pancreatic beta cells in the face of prolonged insulin resistance results in the development of type II diabetes. Ansarullah et al. now describe an inhibitor of beta-cell insulin signalling that, on removal, increases beta-cell mass and improves beta-cell function, with potential as a new way to address beta-cell failure.

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Fig. 1: ELAPOR1 suppresses autocrine signalling in beta cells.

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Authors and Affiliations

  1. Charles Perkins Centre, University of Sydney, Sydney, New South Wales, Australia

    James G. Burchfield & David E. James

  2. School of Life and Environmental Sciences, University of Sydney, Sydney, New South Wales, Australia

    James G. Burchfield & David E. James

  3. Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia

    David E. James

Authors
  1. James G. Burchfield
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  2. David E. James
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Correspondence to David E. James.

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The authors declare no competing interests.

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Burchfield, J.G., James, D.E. A co-receptor that represses beta-cell insulin action. Nat Metab 3, 126–127 (2021). https://doi.org/10.1038/s42255-021-00352-4

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