Skip to main content
SpringerLink
Log in

FUNCTIONAL GENOMICS

Caught in the genetic network: a novel regulator of lipid metabolism

  • News & Views
  • Published:

From Nature Metabolism

View current issue Submit your manuscript

Genetic-interaction mapping and co-essentiality analyses in human cells reveal the orphan gene C12orf49 (also known as SPRING1) as a novel regulator of lipid-metabolism homeostasis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1: The genetic interactions and co-essentiality networks of C12orf49 reflect its role in the SREBP pathway.

References

  1. Robinson, J. L. et al. Sci. Signal. 13, eaaz1482 (2020).

    Article  CAS  Google Scholar 

  2. Aregger, M. et al. Nat. Metab. https://doi.org/10.1038/s42255-020-0211-z (2020).

  3. Bayraktar, E. C. et al. Nat. Metab. https://doi.org/10.1038/s42255-020-0206-9 (2020).

  4. Costanzo, M. et al. Cell 177, 85–100 (2019).

    Article  CAS  Google Scholar 

  5. Horton, J. D., Goldstein, J. L. & Brown, M. S. J. Clin. Invest. 109, 1125–1131 (2002).

    Article  CAS  Google Scholar 

  6. Boyle, E. A., Pritchard, J. K. & Greenleaf, W. J. Mol. Syst. Biol. 14, e8594 (2018).

    Article  Google Scholar 

  7. Kim, E. et al. Life Sci. Alliance 2, e201800278 (2019).

    Article  Google Scholar 

  8. Loregger, A. et al. Nat. Commun. 11, 1128 (2020).

    Article  CAS  Google Scholar 

  9. Klarin, D. et al. Nat. Genet. 50, 1514–1523 (2018).

    Article  CAS  Google Scholar 

  10. Angeles, T. S. & Hudkins, R. L. Expert Opin. Drug Discov. 11, 1187–1199 (2016).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences, Vienna, Austria

    Enrico Girardi & Giulio Superti-Furga

  2. Center for Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria

    Giulio Superti-Furga

Authors
  1. Enrico Girardi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Giulio Superti-Furga
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding authors

Correspondence to Enrico Girardi or Giulio Superti-Furga.

Ethics declarations

Competing interests

The authors declare no competing interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Girardi, E., Superti-Furga, G. Caught in the genetic network: a novel regulator of lipid metabolism. Nat Metab 2, 483–484 (2020). https://doi.org/10.1038/s42255-020-0218-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s42255-020-0218-5

  • Springer Nature Limited

Search

Navigation