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NON-ALCOHOLIC STEATOHEPATITIS AND HAEMOSTASIS

The mega-importance of de novo lipogenesis in platelet production

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Aberrant upregulation of de novo lipogenesis is linked to non-alcoholic fatty liver disease and some cancers. A new study by Kelly et al. finds that inhibiting this pathway by blocking the activity of acetyl-CoA carboxylase has unexpected effects on the formation of platelets from megakaryocytes within the bone marrow of primates but not rodents, thus suggesting clinical implications for de novo lipogenesis inhibitors as a new class of therapeutics.

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Fig. 1: Schematic outlining platelet production and the proposed mechanisms through which DNL inhibitors inhibit this process.

References

  1. Softic, S., Cohen, D. E. & Kahn, C. R. Dig. Dis. Sci. 61, 1282–1293 (2016).

    Article  CAS  Google Scholar 

  2. Arnold, D. M., Nazi, I. & Kelton, J. G. Expert Opin. Investig. Drugs 18, 805–819 (2009).

    Article  CAS  Google Scholar 

  3. Sebo, Z. L. et al. Endocr. Rev. 40, 1187–1206 (2019).

    Article  Google Scholar 

  4. Valet, C. et al. Cell Rep. 32, 107875 (2020).

    Article  CAS  Google Scholar 

  5. Siddiqui, N. F., Shabrani, N. C., Kale, V. P. & Limaye, L. S. Cytotherapy 13, 114–128 (2011).

    Article  CAS  Google Scholar 

  6. Kelly, K. L. et al. Nat. Metab. https://doi.org/10.1038/s42255-020-00272-9 (2020).

  7. Lepropre, S. et al. Blood 132, 1180–1192 (2018).

    Article  CAS  Google Scholar 

  8. Bashour, F. N., Teran, J. C. & Mullen, K. D. Am. J. Gastroenterol. 95, 2936–2939 (2000).

    Article  CAS  Google Scholar 

  9. Lally, J. S. V. et al. Cell Metab. 29, 174–182 (2019).

    Article  CAS  Google Scholar 

  10. Pinkosky, S. L. et al. Nat. Commun. 7, 13457 (2016).

    Article  CAS  Google Scholar 

  11. Ray, K. K. et al. N. Engl. J. Med. 380, 1022–1032 (2019).

    Article  CAS  Google Scholar 

  12. Horn, P. & Newsome, P. N. Expert Opin. Ther. Targets 24, 175–186 (2020).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Department of Medicine, McMaster University, Hamilton, Ontario, Canada

    Ishac Nazy, Donald M. Arnold & Gregory R. Steinberg

  2. Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

    Ishac Nazy & Gregory R. Steinberg

  3. Centre for Transfusion Research, McMaster University, Hamilton, Ontario, Canada

    Ishac Nazy & Donald M. Arnold

  4. Centre for Metabolism, Obesity and Diabetes Research, McMaster University, Hamilton, Ontario, Canada

    Gregory R. Steinberg

Authors
  1. Ishac Nazy
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  2. Donald M. Arnold
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  3. Gregory R. Steinberg
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Corresponding author

Correspondence to Gregory R. Steinberg.

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Competing interests

G.R.S. is a cofounder and shareholder of Espervita Therapeutics. McMaster University has received funding from Espervita Therapeutics, Esperion Therapeutics and Poxel Pharma for research conducted by the laboratory of G.R.S. G.R.S. has received consulting or speaking fees from Allysta Pharmaceuticals, Eli Lilly, Esperion Therapeutics, Merck, Poxel Pharma and Takeda. I.N. and D.M.A. have no conflicts of interest to report.

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Nazy, I., Arnold, D.M. & Steinberg, G.R. The mega-importance of de novo lipogenesis in platelet production. Nat Metab 2, 999–1000 (2020). https://doi.org/10.1038/s42255-020-00282-7

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