Cells contributing to atherosclerotic disease are highly plastic and can shift their phenotype in a changing microenvironment. A study in Nature Metabolism now reveals that transforming growth factor-β (TGF-β) can transform endothelial cells into pro-inflammatory cells and that inhibition of TGF-β-receptor signalling in the endothelium can reverse atherosclerosis in mice.
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Howe, K.L., Fish, J.E. Transforming endothelial cells in atherosclerosis. Nat Metab 1, 856–857 (2019). https://doi.org/10.1038/s42255-019-0100-5
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DOI: https://doi.org/10.1038/s42255-019-0100-5
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