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SENESCENCE

NAD+: a metabolic knob fine-tuning inflammation during senescence

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The senescence-associated secretory phenotype (SASP) is responsible for the deleterious effects of senescent cells in ageing and cancer. A new study shows that NAD+ metabolism can regulate the pro-inflammatory SASP, thereby promoting tumorigenesis.

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Fig. 1: NAD+ metabolism regulates the pro-inflammatory SASP and can promote tumour progression.

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Authors and Affiliations

  1. MRC London Institute of Medical Sciences (LMS), London, UK

    Pia Pernille Søgaard & Jesús Gil

  2. Institute of Clinical Sciences (ICS), Faculty of Medicine, Imperial College London, London, UK

    Pia Pernille Søgaard & Jesús Gil

Authors
  1. Pia Pernille Søgaard
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  2. Jesús Gil
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Corresponding author

Correspondence to Jesús Gil.

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Competing interests

J.G. owns equity in and is a consultant for Unity Biotechnology. Unity Biotechnology funds research on senolytics in the laboratory of J.G. J.G is a named inventor in a filed MRC patent related to senolytic therapies (PCT/GB2018/051437) that has been licensed to Unity Biotechnology.

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Søgaard, P.P., Gil, J. NAD+: a metabolic knob fine-tuning inflammation during senescence. Nat Metab 1, 310–311 (2019). https://doi.org/10.1038/s42255-019-0047-6

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