Many commonly used inbred mouse strains carry random mutations that can affect the results of metabolic studies. Yet, awareness of such mutations as a source for experimental variation and seemingly contradictory results is lacking. It is time that scientists pay more attention to the identification, tracking and accurate reporting of mouse strains used in experiments.
References
Mouse Genome Sequencing Consortium et al. Nature 420, 520–562 (2002).
Noben-Trauth, K., Zheng, Q. Y. & Johnson, K. R. Nat. Genet. 35, 21–23 (2003).
Johnson, K. R., Zheng, Q. Y., Bykhovskaya, Y., Spirina, O. & Fischel-Ghodsian, N. Nat. Genet. 27, 191–194 (2001).
Lapuente-Brun, E. et al. Science 340, 1567–1570 (2013).
Cogliati, S. et al. Nature 539, 579–582 (2016).
Mattapallil, M. J. et al. Invest. Ophthalmol. Vis. Sci. 53, 2921–2927 (2012).
Kumar, V. et al. Science 342, 1508–1512 (2013).
Mahajan, V. S. et al. Cell Rep. 15, 1901–1909 (2016).
Fischer, M., Kosyakova, N., Liehr, T. & Dobrowolski, P. Mamm. Genome 28, 31–37 (2016).
Specht, C. G. & Schoepfer, R. BMC Neurosci. 2, 11 (2001).
Freeman, H. C., Hugill, A., Dear, N. T., Ashcroft, F. M. & Cox, R. D. Diabetes 55, 2153–2156 (2006).
Picard, M. et al. Proc. Natl Acad. Sci. USA 112, E6614–E6623 (2015).
Fan, W. et al. Science 319, 958–962 (2008).
Simon, M. M. et al. Genome Biol. 14, R82 (2013).
Mulligan, M. K. et al. Genes Brain Behav. 7, 677–689 (2008).
Latorre-Pellicer, A. et al. Nature 535, 561–565 (2016).
Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M. & Altman, D. G. PLoS Biol. 8, e1000412 (2010).
Zurita, E. et al. Transgenic Res. 20, 481–489 (2010).
Acknowledgements
I would like to thank J. Fritsche for his inspiring effort to extend the awareness on the genetic variability in experimental mouse strains; and S. Cogliati, D. Sancho and V. Enriquez-Zarralanga for critical reading of the manuscript. My team’s work is supported by MCIU; SAF2015-65633-R; CIBERFES (CB16/10/00282); and the HFSP (RGP0016/2018). The CNIC is supported by MCIU and Pro-CNIC Foundation and is a SO-MINECO (award SEV-2015-0505).
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Enríquez, J.A. Mind your mouse strain. Nat Metab 1, 5–7 (2019). https://doi.org/10.1038/s42255-018-0018-3
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DOI: https://doi.org/10.1038/s42255-018-0018-3
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