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FIBROSIS

A metabolic strategy to reverse fibrosis?

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Fibrosis is characterized by excessive extracellular matrix (ECM) production relative to catabolism. A new study shows that the fuel choice of fibroblasts impacts this balance, with glycolysis promoting ECM synthesis and fatty acid oxidation stimulating ECM degradation.

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Authors and Affiliations

  1. Department of Chemistry and Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA

    Joshua D. Rabinowitz

  2. Department of Medicine, Section of Pulmonary and Critical Care Medicine, University of Chicago, Chicago, IL, USA

    Gökhan M. Mutlu

Authors
  1. Joshua D. Rabinowitz
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  2. Gökhan M. Mutlu
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Correspondence to Joshua D. Rabinowitz.

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The authors declare no competing interests.

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Rabinowitz, J.D., Mutlu, G.M. A metabolic strategy to reverse fibrosis?. Nat Metab 1, 12–13 (2019). https://doi.org/10.1038/s42255-018-0013-8

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