Gut microbes have enzymes that break down the heavily glycosylated mucin protein of host animals, but known enzymes recognize only one glycan chain. Now, bioinformatic exploration has uncovered a family of mucinases that targets dense sugar residues.
References
Hansson, G. C. Annu. Rev. Biochem. 89, 769–793 (2020).
Shon, D. J., Kuo, A., Ferracane, M. J. & Malaker, S. A. Biochem. J. 478, 1585–1603 (2021).
Narimatsu, Y. et al. Nat. Catal. https://doi.org/10.1038/s41929-024-01116-5 (2024).
Luis, A. S. & Hansson, G. C. Cell Host Microbe 31, 1087–1100 (2023).
Perdam, K. et al. Nat. Biotechnol. https://doi.org/10.1038/s41587-023-01840-6 (2023).
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Fushinobu, S. Taking a walk to find new mucinases. Nat Catal 7, 345–346 (2024). https://doi.org/10.1038/s41929-024-01145-0
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DOI: https://doi.org/10.1038/s41929-024-01145-0
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