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CO2 fixation

Divide and conquer towards synthetic autotrophy

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With climate change concerns deepening, CO2 fixation pathways to produce value-added chemicals are currently of interest. Now, synthetic biology and machine learning help developing such a pathway across modules that have been tested in vivo in Escherichia coli for the production of acetyl coenzyme A.

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Fig. 1: Modular design of the THETA cycle for optimal CO2 fixation.

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Authors and Affiliations

  1. Biosciences Center, National Renewable Energy Laboratory, Golden, CO, USA

    Wei Xiong

  2. Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, China

    Yanhe Ma

  3. National Center of Technology Innovation for Synthetic Biology, Tianjin, China

    Yanhe Ma

Authors
  1. Wei Xiong
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  2. Yanhe Ma
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Corresponding authors

Correspondence to Wei Xiong or Yanhe Ma.

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The authors declare no competing interests.

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Xiong, W., Ma, Y. Divide and conquer towards synthetic autotrophy. Nat Catal 6, 1113–1114 (2023). https://doi.org/10.1038/s41929-023-01084-2

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