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Polyketide Biosynthesis

An artificial pathway for polyketide biosynthesis

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Polyketide synthases are multi-domain enzymes that catalyse the construction of many bioactive natural products. Now, some of the inefficiencies and limitations of these systems have been solved by designing an artificial pathway for carbon–carbon bond formation via iterative rounds of non-decarboxylative thio-Claisen reactions.

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Fig. 1: Natural and artificial pathways to polyketide products.

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Authors and Affiliations

  1. Department of Chemistry, NC State University, Raleigh, NC, USA

    Anuran K. Gayen, Lindsay Nichols & Gavin J. Williams

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  1. Anuran K. Gayen
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  2. Lindsay Nichols
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  3. Gavin J. Williams
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Correspondence to Gavin J. Williams.

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The authors declare no competing interests.

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Gayen, A.K., Nichols, L. & Williams, G.J. An artificial pathway for polyketide biosynthesis. Nat Catal 3, 536–538 (2020). https://doi.org/10.1038/s41929-020-0483-4

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