Enzymes require many, often hundreds, of amino acid residues arranged in a protein fold to promote catalysis. Now, self-assembly of a single amino acid — phenylalanine — in the presence of zinc is shown to form supramolecular structures that promote hydrolysis better than natural enzymes on a weight basis.
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References
Zozulia, O., Dolan, M. A. & Korendovych, I. V. Chem. Soc. Rev. 47, 3621–3639 (2018).
Makam, P. et al. Nat. Catal. https://doi.org/10.1038/s41929-019-0348-x (2019).
Krishnamurthy, V. M. et al. Chem. Rev. 108, 946–1051 (2008).
Adler-Abramovich, L. et al. Nat. Chem. Biol. 8, 701–706 (2012).
Zastrow, M. L., Peacock, A. F. A., Stuckey, J. A. & Pecoraro, V. L. Nat. Chem. 4, 118–123 (2012).
Cobb, A. K. & Pudritz, R. E. Astophys. J. 783, 140 (2014).
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Makhlynets, O.V., Korendovych, I.V. A single amino acid enzyme. Nat Catal 2, 949–950 (2019). https://doi.org/10.1038/s41929-019-0379-3
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DOI: https://doi.org/10.1038/s41929-019-0379-3
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