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Engineering imine reductases for industrial applications

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Imine reductases are promising catalysts, facilitating a direct stereoselective route to secondary amines. Now, protein engineering has created stable and efficient variants that allow their application in kilogram-scale synthesis.

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Fig. 1: Stereoselective imine reductions and reductive aminations catalysed by imine reductases.

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  1. Institute of Biochemistry, University of Greifswald, Greifswald, Germany

    Matthias Höhne

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  1. Matthias Höhne
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Correspondence to Matthias Höhne.

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Höhne, M. Engineering imine reductases for industrial applications. Nat Catal 2, 841–842 (2019). https://doi.org/10.1038/s41929-019-0366-8

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