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Enzyme catalysis under pressure

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A strategy using pressure was devised to structurally identify conformational transitions in protein ensembles, allowing the rational prediction of mutations that induce pressure-driven enzyme activation. These results highlight the power of flexibility–function analyses in protein engineering design and applications.

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Fig. 1: Rational prediction of mutations that induce pressure-driven enzyme activation.

References

  1. Campbell, E. et al. Nat. Chem. Biol. 12, 944–50 (2016).

    Article  CAS  Google Scholar 

  2. Narayanan, C. et al. Structure 26, 426–36 (2018).

    Article  CAS  Google Scholar 

  3. Stiller, J. B. et al. Nat. Catal. https://doi.org/10.1038/s41929-019-0307-6 (2019).

  4. Lisi, G. P. & Loria, J. P. Prog. Nucl. Magn. Reson. Spectrosc. 92–93, 1–17 (2016).

    Article  Google Scholar 

  5. Akasaka, K. Chem. Rev. 106, 1814–35 (2006).

    Article  CAS  Google Scholar 

  6. Wilding, M., Hong, N., Spence, M., Buckle, A. M. & Jackson, C. J. Biochem. Soc. Trans. 47, 701–11 (2019).

    Article  CAS  Google Scholar 

  7. Davey, J. A., Damry, A. M., Goto, N. K. & Chica, R. A. Nat. Chem. Biol. 13, 1280–85 (2017).

    Article  CAS  Google Scholar 

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  1. Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique (INRS), Université du Québec, Laval, QC, Canada

    Nicolas Doucet

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  1. Nicolas Doucet
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Correspondence to Nicolas Doucet.

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Doucet, N. Enzyme catalysis under pressure. Nat Catal 2, 646–647 (2019). https://doi.org/10.1038/s41929-019-0326-3

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