S-adenosylmethionine (SAM)-dependent methyltransferase enzymes have significant synthetic potential, but their utility as biocatalysts has been limited by the availability of SAM. An elegant and simple method addressing this long-standing problem has now been developed using a halide methyltransferase (HMT) enzyme for SAM regeneration in vitro.
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Micklefield, J. Streamlined recycling of S-adenosylmethionine. Nat Catal 2, 644–645 (2019). https://doi.org/10.1038/s41929-019-0323-6
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DOI: https://doi.org/10.1038/s41929-019-0323-6
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