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Epigenetics

Inheritance of directed DNA cytosine methylation in mammals

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A recent study performed directed C5-cytosine methylation of CpG islands to demonstrate that acquired methylation at critical loci could be reestablished for multiple generations in mice. This work provides a manipulatable system to examine how non-genetic information is transmitted across generations to regulate complex phenotypes.

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Fig. 1: Directed DNA methylation transgenerationally inhibits Ankrd26 or Ldlr expression and drives obesity or hypercholesterolemia in mice.

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Authors and Affiliations

  1. Department of Pediatrics, Washington University School of Medicine, St. Louis, MO, USA

    Gautam Sarkar & Eric Lieberman Greer

  2. Department of Genetics, Washington University School of Medicine, St. Louis, MO, USA

    Gautam Sarkar & Eric Lieberman Greer

Authors
  1. Gautam Sarkar
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  2. Eric Lieberman Greer
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Correspondence to Eric Lieberman Greer.

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The authors declare no competing interests.

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Sarkar, G., Greer, E.L. Inheritance of directed DNA cytosine methylation in mammals. Lab Anim 52, 105–107 (2023). https://doi.org/10.1038/s41684-023-01158-5

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  • DOI: https://doi.org/10.1038/s41684-023-01158-5

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