Skip to main content
Log in

NEUROSCIENCE

Building vascular roadmaps: A novel toolset for visualizing and annotating whole mouse brain vasculature

  • News & Views
  • Published:
Lab Animal

Vasculature has an essential role both in central nervous system health and diseases. A new optimized imaging and analysis pipeline helps to characterize blood vessel network topology and plasticity across large regions in detail.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1: Whole brain vascular imaging and analysis pipeline.

References

  1. Kisler, K., Nelson, A. R., Montagne, A. & Zlokovic, B. V. Nat. Rev. Neurosci. (2017) https://doi.org/10.1038/nrn.2017.48.

    Article  CAS  Google Scholar 

  2. Sweeney, M. D., Kisler, K., Montagne, A., Toga, A. W. & Zlokovic, B. V. Nat. Neurosci. 21, 1318–1331 (2018).

    Article  CAS  Google Scholar 

  3. Iadecola, C. Neuron 96, 17–42 (2017).

    Article  CAS  Google Scholar 

  4. Tsai, P. S. et al. J. Neurosci. 29, 14553–14570 (2009).

    Article  CAS  Google Scholar 

  5. Wu, J. et al. NeuroImage 87, 199–208 (2014).

    Article  Google Scholar 

  6. Hörl, D. et al. Nat. Methods 16, 870–874 (2019).

    Article  Google Scholar 

  7. Bria, A. & Iannello, G. BMC Bioinformatics 13, 316 (2012).

    Article  Google Scholar 

  8. Kirst, C. et al. Cell 180, 780–795.e25 (2020).

    Article  CAS  Google Scholar 

  9. Vanlandewijck, M. et al. Nature 554, 475–480 (2018).

    Article  CAS  Google Scholar 

  10. Zhang, H., Prabhakar, P., Sealock, R. & Faber, J. E. J. Cereb. Blood Flow Metab. 30, 923–934 (2010).

    Article  CAS  Google Scholar 

  11. Montagne, A. et al. Blood-brain barrier breakdown in the aging human hippocampus. Neuron 85, 296–302 (2015).

    Article  CAS  Google Scholar 

  12. Montagne, A. et al. Nat. Med. (2018) https://doi.org/10.1038/nm.4482.

    Article  CAS  Google Scholar 

  13. Bell, R. D. et al. Neuron 68, 409–427 (2010).

    Article  CAS  Google Scholar 

  14. Kisler, K. et al. Nat. Neurosci. 20, 406–416 (2017).

    Article  CAS  Google Scholar 

  15. Kisler, K. et al. Front. Cell. Neurosci 14, 27 (2020).

    Article  Google Scholar 

  16. Nikolakopoulou, A. M. et al. Nat. Neurosci. 22, 1089–1098 (2019).

    Article  CAS  Google Scholar 

  17. Berthiaume, A.-A. et al. Cell Rep 22, 8–16 (2018).

    Article  CAS  Google Scholar 

  18. Sagare, A. P., Sweeney, M. D., Makshanoff, J. & Zlokovic, B. V. Neurosci. Lett. 607, 97–101 (2015).

    Article  CAS  Google Scholar 

  19. Zipfel, G. J., Han, H., Ford, A. L. & Lee, J.-M. Stroke 40, S16–19 (2009).

    Article  Google Scholar 

  20. Thomas, T., Thomas, G., McLendon, C., Sutton, T. & Mullan, M. Nature 380, 168–171 (1996).

    Article  CAS  Google Scholar 

  21. Iadecola, C. et al. Nat. Neurosci. 2, 157–161 (1999).

    Article  CAS  Google Scholar 

  22. Faraco, G. et al. Nat. Neurosci. 21, 240–249 (2018).

    Article  CAS  Google Scholar 

  23. Sweeney, M. D., Zhao, Z., Montagne, A., Nelson, A. R. & Zlokovic, B. V. Physiol. Rev. 99, 21–78 (2019).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kassandra Kisler.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kisler, K., Huuskonen, M.T. & Zlokovic, B.V. Building vascular roadmaps: A novel toolset for visualizing and annotating whole mouse brain vasculature. Lab Anim 49, 175–176 (2020). https://doi.org/10.1038/s41684-020-0556-7

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/s41684-020-0556-7

  • Springer Nature America, Inc.

Navigation