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Illuminating cortactin structure and function at actin filament branches

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Stabilization of a branch structure would intuitively suggest a direct connection between trunk and bough, but in actin filament networks, cortactin clamps the branching Arp2/3 complex to the daughter filament. This has fundamental consequences for mechanistic understanding of actin branch turnover and cortactin biology.

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Fig. 1: The cellular and molecular roles of cortactin.

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Acknowledgements

Research in the Rottner and Bieling laboratories is supported by the German Research Foundation (DFG) with grants to K.R. (GRK2223 and RO 2414/8-1) and P.B. (BI 1998/2-1), Helmholtz Association of German Research Centers (K.R.) and the Max Planck Society (P.B.). We thank M. Boiero Sanders (MPI Dortmund) for creating the molecular scheme in Fig. 1, based on published structures, and the members of our laboratories for input and discussions.

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Authors and Affiliations

  1. Department of Cell Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany

    Klemens Rottner

  2. Division of Molecular Cell Biology, Zoological Institute, Technische Universität Braunschweig, Braunschweig, Germany

    Klemens Rottner

  3. Department of Systemic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany

    Peter Bieling

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  1. Klemens Rottner
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  2. Peter Bieling
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Correspondence to Klemens Rottner or Peter Bieling.

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Rottner, K., Bieling, P. Illuminating cortactin structure and function at actin filament branches. Nat Struct Mol Biol 31, 739–741 (2024). https://doi.org/10.1038/s41594-024-01297-4

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