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Pre-mRNA splicing

Illuminating the role of chaperones in spliceosome biogenesis and recycling

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Spliceosome biogenesis and recycling remains a largely unexplored area. Two papers now reveal how protein chaperones remodel the 20S U5 snRNP, leading to formation of the U4/U6.U5 tri-snRNP.

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Fig. 1: Schematic of U5 snRNP during the transition from the 20S U5 snRNP to the U4/U6.U5 tri-snRNP.

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Acknowledgements

The author acknowledges UK Medical Research Council grant MC_UP_1201/30 for funding.

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  1. MRC Laboratory of Molecular Biology, Cambridge, UK

    Suyang Zhang

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  1. Suyang Zhang
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Correspondence to Suyang Zhang.

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Zhang, S. Illuminating the role of chaperones in spliceosome biogenesis and recycling. Nat Struct Mol Biol 31, 735–736 (2024). https://doi.org/10.1038/s41594-024-01293-8

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