Targeted biologics delivery requires programming multicomponent protein nanomaterials to enable selective targeting and response to environment changes in a single unified framework. A novel protein nanoparticle platform has been designed to modulate cell-surface target specificity, cargo packaging, and pH-dependent release of encapsulated cargo, providing exciting possibilities in biologics delivery.
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This is a summary of: Yang, E. C. et al. Computational design of non-porous pH-responsive antibody nanoparticles. Nat. Struct. Mol. Biol. https://doi.org/10.1038/s41594-024-01288-5 (2024).
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Custom protein nanoparticles for targeted drug delivery. Nat Struct Mol Biol (2024). https://doi.org/10.1038/s41594-024-01289-4
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DOI: https://doi.org/10.1038/s41594-024-01289-4
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